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About Trusted Kidney

Adoption of Trusted Kidney in biopsy evaluation can provide more accurate and precise information, that has the potential to decrease an institution’s organ discard rate.

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Why are kidneys discarded?

Biopsy evaluation is critical in determining the health of a donor kidney, but interpretations are inconsistent and overestimate damage. Biopsy results are the #1 factor leading to organ discard.1 Up to 20% of healthy donor kidneys are discarded due to inaccurate biopsy interpretation.2

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Evaluation errors cause more discards, contributing to the current kidney shortage. Organs transplanted based on an inaccurate biopsy can also lead to poor patient outcomes.

Our Solution

Using Trusted Kidney can produce the most accurate biopsy results available. Our advanced Deep Learning software quantifies glomerulosclerosis with precision. Pathologists can review and update evaluations rapidly with a user-friendly tool.

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Trusted Kidney has the potential to lower pathologist error rate by 22% and decrease the likelihood of unnecessary organ discard by 37%.3 More accurate evaluations could mean more transplants, and better outcomes for patients.

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Trusted Kidney is a secure, cloud-based tool for pathologists.
We partner with Organ Procurement Organizations and pathology laboratories. Adding Trusted Kidney to your workflow is the next step you can take to optimize donor organ availability and outcomes.

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How it works

More Accurate

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Trusted Kidney software assists pathologists by counting glomeruli in biopsy tissue, providing a global glomerulosclerosis score. Results are superior to manual quantitation by general surgical pathologists.

User-Friendly & Rapid

Trusted Kidney is designed to integrate seamlessly in an existing digital pathology workflow. Developed by pathologists – for pathologists, the tool enables rapid verification and modification to biopsy results.

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More Comprehensive

Human pathologists only review one slide at a time. In contrast, Trusted Kidney evaluates all slides in parallel. The result is maximum efficiency and precision. Our tool harnesses AI for pathologists, enabling rapid review of more sections than a human could evaluate.

Trusted Kidney reviews all available sections to provide a more comprehensive evaluation of organ health. Trusted Kidney review of 4 slides has been shown to reduce the chance of evaluation error to 2% (compared to a 14% chance of error for a single slide evaluation).

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© 2025 by Trusted Kidney

Info@trustedkidney.com • BioGenerator Labs, Suite 300 - 4340 Duncan Avenue • St Louis, MO 63110

Trusted Kidney is for Research Use Only and is not for use in diagnostic procedures.

1 Mohan S., et al. “Factors leading to the discard of deceased donor kidneys in the United States.” Kidney Int. 2018:94:187-198.

​2  Azancot MA, Moreso F, Salcedo M, Cantarell C, Perello M, Torres IB, et al.: The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors. Kidney Int, 85: 1161-1168, 2014 10.1038/ki.2013.461
3  Marsh JN, Liu TC, Wilson PC, Swamidass SJ, Gaut JP. “Development and validation of a deep learning model to quantify glomerulosclerosis in kidney biopsy specimens.” JAMA Netw Open. 2021:4(1):e2030939.
 

SOURCES:

Deep Learning Global Glomerulosclerosis in Transplant Kidney Frozen Sections”, Marsh JN, Matlock MK, Kudose S, Liu TC, Stappenbeck TS, Gaut JP, Swamidass SJ., IEEE Trans Med Imaging. 2018 Dec;37(12):2718-2728. doi: 10.1109/TMI.2018.2851150

Gaut J, Marsh J, Blackford M, Swamidass V, Berry R, Swamidass S. Deployment of a Deep Learning Model to Assist Pathologists with Donor Kidney Biopsy Evaluation. 2021. Poster presented at the Digital Pathology Association annual conference.

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